Music Reduces Pain and Increases Resting State fMRI Bold Signal Amplitude in the Left Angular Gyrus in Fibromyalgia Patients


Frontiers in Psychology




Music reduces pain in fibromyalgia (FM), a chronic pain disease, but the functional neural correlates of music-induced analgesia (MIA) are still largely unknown. We recruited FM patients (n = 22) who listened to their preferred relaxing music and an auditory control (pink noise) for 5 min without external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD signal was evident in the left angular gyrus (lAnG) after listening to music, which in turn, correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the lAnG showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex (rdlPFC), the left caudate (lCau), and decreased connectivity with right anterior cingulate cortex (rACC), right supplementary motor area (rSMA), precuneus and right precentral gyrus (rPreG). Pain intensity (PI) analgesia was correlated (r = 0.61) to the connectivity of the lAnG with the rPreG. Our results show that MIA in FM is related to top-down regulation of the pain modulatory network by the default mode network (DMN). (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Music and Health Institute Terms

Analgesic Intake; Chronic Pain; Fibromyalgia; Functional Magnetic Resonance Imaging; Medication Use; Music Listening; Music Medicine; Pain; Pain Management and Control; Pain Severity; Recorded Music Listening

Indexed Terms

fibromyalgia; pain; analgesia; resting state fMRI; BOLD signal; angular gyrus; fALFF; Cingulate Cortex; Functional Magnetic Resonance Imaging

Study Type

Quasi-Experimental Study; Quantitative Methods

PubMed ID


Document Type