Effect of Combined Music and Touch Intervention on Pain Response and Β-endorphin and Cortisol Concentrations in Late Preterm Infants


BMC Pediatrics




BACKGROUND: Preterm neonates undergo many painful procedures as part of their standard care in the neonatal intensive care unit. However, pain treatment is inadequate in many of these routine procedures. In the present study, we investigated the impact and mechanism of combined music and touch intervention (CMT) on the pain response in premature infants.METHODS: Sixty-two preterm neonates (gestational age of RESULTS: In total, 3707 painful procedures were performed on 62 neonates during their hospitalization. The average number of painful procedures in the control group (n = 35.5) was higher than that in the experimental group (n = 29.0) during hospitalization, although no significant difference was reached (P > 0.05). After 2 weeks, the Premature Infant Pain Profile scores were significantly higher in the control group than experimental group (13.000 ± 0.461 vs 10.500 ± 0.850, respectively; P 0.05) or 2 weeks later (162.400 ± 23.580 vs 184.600 ± 21.170, respectively; P > 0.05). However, the serum β-endorphin concentration was higher in the experimental group than in the control group both at the beginning of hospitalization (1.640 ± 0.390 vs 1.179 ± 0.090, respectively; P CONCLUSIONS: CMT might decrease the pain response of preterm neonates by significantly improving the β-endorphin concentration, but not the blood cortisol concentration.TRIAL REGISTRATION: Current Controlled Trials ISRCTN14131492 . Registered on 01 Aug 2016.

Music and Health Institute Terms

Cortisol Levels; Hospital Setting; Infants; Invasive Medical Procedures; Mental Health; Mental Health Hormone Levels; Music Medicine; Music in Combination with Other Techniques; Neonatal Intensive Care; Newborn Infants; Pain; Pain Management and Control; Pain Score or Rating; Premature Infants; Procedural Pain; Stress; Suffering

Indexed Terms

Biomarkers; Combined Modality Therapy; Newborn Infants; Premature Infants; Outcome Assessment (Health Care); Pain Measurement; Single-Blind Method; Hydrocortisone; Premature Infants; Intensive Care, Neonatal; Pain Management; Therapeutic Touch; beta-Endorphin

Study Type

Randomized Controlled Trial; Quantitative Methods

PubMed ID


Document Type