Regional Cerebral Blood Flow Change in a Case of Alzheimer's Disease With Musical Hallucinations

T. Mori
M. Ikeda
R. Fukuhara
Y. Sugawara
S. Nakata
N. Matsumoto
P. J. Nestor
H. Tanabe

Abstract

We examined alteration of regional cerebral blood flow (rCBF) in a case of Alzheimer's disease (AD) patient with musical hallucination. To detect regions related to musical hallucination, single-photon emission computed tomography (SPECT) imaging of the patient and nine sex, age, and cognitive function-matched AD patients without delusions and hallucinations were compared using statistical parametric mapping 99 (SPM99). In comparison with controls, the patient had increased rCBF in left temporal regions and left angular gyrus. This profile could be relevant to the neuroanatomical basis of musical hallucinations.