Neural Basis of Long-term Musical Memory in Cognitively Impaired Older Persons
Alzheimer Disease & Associated Disorders
OBJECTIVE: The objective of this study was to determine whether exposure to long-known music would evoke more extensive activation of brain regions minimally affected by Alzheimer disease (AD) pathology and outside traditional memory networks using a functional magnetic resonance imaging paradigm involving listening to long-known and recently-learned music in older adults with cognitive impairment to provide insight into mechanisms of long-term musical memory preservation in cognitively impaired older persons. METHODS: Seventeen subjects with a diagnosis of mild AD or mild cognitive impairment were recruited for this study. Subjects were scanned using functional magnetic resonance imaging while they performed a music listening task, which included short clips of personally selected music from the patient's past and newly-composed music heard for the first time 60 minutes before scanning. From this task, we obtained group-level maps comparing brain areas associated with long-known and recently-heard music in all subjects. RESULTS: Exposure to long-known music preferentially activated brain regions including the medial prefrontal cortex, precuneus, anterior insula, basal ganglia, hippocampus, amygdala, and cerebellum relative to recently-heard music. These areas are involved in autobiographical memory and associated emotional responses. In addition, they are minimally affected by early stage AD pathology, thus providing a neural basis for long-known musical memory survival. CONCLUSIONS: Long-known music activates a bilateral network of prefrontal, emotional, motor, auditory, and subcortical regions (cerebellum, putamen, limbic structures). This extensive activation, relative to recently-heard music, may offer structural and functional clues as to why long-term musical memory appears to be relatively preserved among cognitively impaired older persons.
Music and Health Institute Terms
Alzheimer's and Related Dementias; Cognitive Abilities; Elderly; Functional Magnetic Resonance Imaging (fMRI); Memory; Music and Cognition; Music Cognition; Music Listening; Neurodegenerative Disorders
Elderly; Alzheimer Disease; Auditory Perception; Brain; Brain Mapping; Cognitive Dysfunction; Magnetic Resonance Imaging; Memory, Episodic
Quasi-Experimental Study; Quantitative Methods
Thaut, M. H.; Fischer, C. E.; Leggieri, M.; Vuong, V.; Churchill, N. W.; Fornazzari, L. R.; and Schweizer, T. A., "Neural Basis of Long-term Musical Memory in Cognitively Impaired Older Persons" (2020). Research on Music and Dementia. 33.