Neurologic Music Therapy Combined With Eeg-tdcs for Upper Motor Extremity Performance in Patients With Corticobasal Syndrome: Study Protocol for a Novel Approach

Journal

Contemporary Clinical Trials

Year

2023

Abstract

BACKGROUND: Corticobasal syndrome (CBS) is an atypical parkinsonian disorder that involves degeneration of brain regions associated with motor coordination and sensory processing. Combining transcranial direct current stimulation (tDCS) with rehabilitation training has been shown to improve upper-limb performance in other disease models. Here, we describe the protocol investigating whether tDCS with neurologic music therapy (NMT) (patterned sensory enhancement and therapeutic instrumental music performance) enhances functional arm/hand performance in individuals with CBS. METHODS: Study participants are randomly assigned to six 30-min sessions (twice per week for 3 weeks) of NMT + either sham tDCS or active tDCS. We aim to stimulate the frontoparietal cortex, which is associated with movement execution/coordination and sensory processing. The hemisphere contralateral to the more affected arm is stimulated (total stimulation current of 2 mA from 5 dime-sized electrodes). Individualized NMT sessions designed to exercise the upper limb are provided. Participants undergo gross/fine motor, cognitive and emotional assessments at baseline and follow-up (one month after the final session). To investigate the immediate effects of tDCS and NMT training, gross /fine motor, affective level, and kinematic parameter measurements using motion sensors are collected before and after each session. Electroencephalography is used to collect electrical neurophysiological responses before, during, and after tDCS+NMT sessions. The study participants, neurologic music therapist and outcome assessor are blinded to whether participants are in the sham or active tDCS group. CONCLUSION: This noninvasive and patient-centered clinical trial for CBS may provide insight into rehabilitation options that are sorely lacking in this population.

Music and Health Institute Terms

Cognitive Abilities; Mobility; Music Therapy; Neurodegenerative Disorders; Observational Measures; Parkinson's Disease; Physiological Measures; Rehabilitation Exercises

Indexed Terms

Corticobasal Degeneration; Stroke; Stroke Rehabilitation; Transcranial Direct Current Stimulation; Corticobasal syndrome; Double-Blind Method; Electroencephalography; Electroencephalography (EEG); Neurologic music therapy (NMT); Randomized Controlled Trials as Topic; Transcranial direct current stimulation (tDCS); Upper Extremity; Upper limb function

Study Type

Randomized Controlled; Trial; Quantitative Methods

Document Type

Article

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