Vocal Music Listening Enhances Poststroke Language Network Reorganization

Journal

eNeuro

Year

2021

Abstract

Listening to vocal music has been recently shown to improve language recovery in stroke survivors. The neuroplasticity mechanisms supporting this effect are, however, still unknown. Using data from a three-arm, single-blind, randomized controlled trial including acute stroke patients (N = 38) and a 3 month follow-up, we set out to compare the neuroplasticity effects of daily listening to self-selected vocal music, instrumental music, and audiobooks on both brain activity and structural connectivity of the language network. Using deterministic tractography, we show that the 3 month intervention induced an enhancement of the microstructural properties of the left frontal aslant tract (FAT) for the vocal music group compared with the audiobook group. Importantly, this increase in the strength of the structural connectivity of the left FAT correlated with improved language skills. Analyses of stimulus-specific activation changes showed that the vocal music group exhibited increased activations in the frontal termination points of the left FAT during vocal music listening compared with the audiobook group from acute to 3 month poststroke stage. The increased activity correlated with the structural neuroplasticity changes in the left FAT. These results suggest that the beneficial effects of vocal music listening on poststroke language recovery are underpinned by structural neuroplasticity changes within the language network and extend our understanding of music-based interventions in stroke rehabilitation.

Music and Health Institute Terms

Aphasia; Cognitive Abilities; Music Listening; Receptive Music Methods; Stroke

Indexed Terms

aphasia; language ability; language network; brain function; clinical article; controlled study; EMBASE keywords; follow up; human; nerve cell plasticity; randomized controlled trial; single blind procedure; stroke patient; stroke rehabilitation; structure activity relation; tractography

Study Type

Systematic Review; Quantitative Methods

Document Type

Article

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