"The Underlying Roles and Neurobiological Mechanisms of Music-based Int" by Liyang Sun, Qin Wang et al.
 

The Underlying Roles and Neurobiological Mechanisms of Music-based Intervention in Alzheimer's Disease: A Comprehensive Review

Journal

Ageing Research Reviews

Year

2024

Abstract

Non-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically delineated. This review aims to holistically review how music-based intervention (MBI) ameliorates abnormal emotion, cognition decline, and behavioral changes in AD patients. We cover several key dimensions: the regulation of MBIs on cerebral blood flow (CBF), their impact on neurotransmission (including GABAergic and monoaminergic transmissions), modulation of synaptic plasticity, and hormonal release. Additionally, we summarize the clinical applications and limitations of active music-based intervention (AMBI), passive music-based intervention (PMBI), and hybrid music-based intervention (HMBI). This thorough analysis enhances our understanding of the role of MBI in AD and supports the development of non-pharmacological therapeutic strategies.

Music and Health Institute Terms

Neurodegenerative Disorders; Alzheimer's and Related Dementias; Cognitive Abilites; Mood; Behavioral State; Music and Cognition; Music Neorscience

Indexed Terms

Alzheimer Disease; Alzheimer's disease; Cerebral blood flow; Cognition; Hormones; Music-based intervention; Neurotransmission; Quality of Life; Synaptic plasticity

Study Type

Editorials, Opinons, Position Papers

PubMed ID

PMID: 38479478

Document Type

Article

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