Psychotherapy With Music Intervention Improves Anxiety, Depression and the Redox Status in Breast Cancer Patients Undergoing Radiotherapy: A Randomized Controlled Clinical Trial
Journal
Cancers
Year
2021
Abstract
The aim of this study was to assess the effects of psychotherapy with music intervention (PMI) on anxiety, depression, redox status, and inflammation in breast cancer patients undergoing radiotherapy (RT). This monocentric randomized clinical trial recruited 60 patients who had a breast cancer operation and were undergoing postoperative RT. Eligible patients were randomized (1:1) in two groups: the control group (CG) received treatment as usual (n = 30), i.e., RT alone; the intervention group (PMI) received RT and psychotherapy with music intervention (n = 30), which was delivered in a group setting. Five patients were excluded after randomization. Assessments were performed at baseline (T0), at the end of RT (T1), and three months after the end of RT (T2). The main objectives of the study were the assessment of anxiety/depression, plasma glutathione (GSH), and thiobarbituric acid reactive substances (TBARS) in the two arms of the study. Our findings revealed a positive effect of PMI on anxiety, depression, resilience, and quality of life. Furthermore, a positive effect of PMI on redox status was found for the first time. Thus, in the PMI group, we found a significant increase of GSH (mean change 2.2 95%, CI 0.7 to 3.7) and a significant reduction of TBARS (mean change −1.1 95%, CI −1.8 to −0.3) at T2 vs. T0.
Music and Health Institute Terms
Anxiety; Breast Cancer; Cancer; Depression; Mood; Music and Healing; Music-based Interventions; Postoperative Patients; Quality of Life; Radiation Therapy; Resilience
Indexed Terms
quality of life; controlled study; human; randomized controlled trial; clinical effectiveness; major clinical study; cancer patient; anxiety disorder; breast cancer; cancer radiotherapy; depression; oxidation reduction reaction; anxiety assessment; cancer surgery; depression assessment; inflammation; mood disorder; open study; parallel design; protein blood level; psychological resilience
Study Type
Quasi-Experimental Study; Quantitative Methods
Document Type
Article
Recommended Citation
Zeppegno, P., Krengli, M., Ferrante, D., Bagnati, M., Burgio, V., Farruggio, S., Rolla, R., Gramaglia, C., & Grossini, E. (2021). Psychotherapy With Music Intervention Improves Anxiety, Depression and the Redox Status in Breast Cancer Patients Undergoing Radiotherapy: A Randomized Controlled Clinical Trial. Cancers, 13 (8) Retrieved from https://remix.berklee.edu/mhi-citations/1991